A Simple Zinc-Mediated Method for Selenium Addition to Michael Acceptors

Copper-catalyzed asymmetric conjugate addition of organometallic reagents to extended Michael acceptors

The copper-catalyzed asymmetric conjugate addition (ACA) of nucleophiles onto polyenic Michael acceptors represents an attractive and powerful methodology for the synthesis of relevant chiral molecules, as it enables in a straightforward manner the sequential generation of two or more stereogenic centers. In the last decade, various chiral copper-based catalysts were evaluated in combination wi...

Enantioselective organocatalytic conjugate addition of aldehydes to vinyl sulfones and vinyl phosphonates as challenging Michael acceptors.

Chiral framework: Chiral amines with pyrrolidine frameworks catalyze the enantioselective conjugate addition of a wide range of aldehydes to various vinyl sulfones and vinyl phosphonates in high yields and with enantioselectivities up to >99 % ee (see scheme). The high versatility of the Michael adducts is exemplified by various functionalizations with conservation of the optical purity.Chiral ...

A New Approach to the Synthesis of (±)-Methyl Jasmonate and (±)-Baclofen via Conjugated Addition of Oxazoline Cyanocuprate to Michael Acceptors

Ammonium monovanadate: a versatile and reusable catalyst for Friedel-Crafts alkylation and Michael addition of indoles

Ammonium monovanadate (NH4VO3) has been devoted as an efficient, commercially available, eco-friendly and reusable catalyst for the synthesis of bis(indolyl)methanes (BIMs), oxindole derivatives and also Michael adducts of indoles at 50 °C under solvent-free conditions. The reusability of this solid acid catalyst in addition with its selectivity has also been examined.

A Simple Method to Improve Hazelnut Grafting

Hazelnuts are usually propagated by suckers or layering. However, other methods of propagation have been tested with variable results. Grafting is a method that has a few advantages such as fast multiplication rate, earlier fruiting and reducing sucker removal cost on specific rootstocks. Unfortunately, grafting is difficult due to slow formation of callus in hazelnuts. Here, we report the hypo...